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KMID : 1234920160160020079
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Journal of Korean Oriental Association for Study of Obesity
2016 Volume.16 No. 2 p.79 ~ p.84
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Effects of Citri Reticulatae Viride Pericarpium on 4-Hydroxynonenal-Induced Inflammation in PC12 Cells
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Ye Young-Jun
Kim Youn-Sub
Kang Mi-Suk
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Abstract
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Objectives: The purpose of this study was to observe the effects of Citri Reticulatae Viride Pericarpium (CP) on 4-Hydroxynonenal (4-HNE)-induced inflammation in PC12 cells.
Methods: 4-HNE was treated in PC12 cell to cause inflammatory response, and then treated with CP water extract at 25, 50, and 100 μg/ml. The phosphorylation of Jun N-terminal kinase (JNK) and the expression of NF-кB in PC12 cells were determined by Western blot, respectively.
Results: The phosphorylation of JNK was significantly decreased in 4-HNE-stimulated PC12 cell by the treatment of CP extract at 25 μg/ml. The 4-HNE-induced expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) p65 in nuclear of the cells was significantly decreased in PC12 cell by treatment with CP extract at 25, 50, and 100 μg/ml.
Conclusions: These results suggest that CP water extract has an anti-inflammatory activity through suppressing the JNK and NF-кB activation.
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KEYWORD
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Citri Reticulatae Viride Pericarpium, 4-HNE, pJNK, pNF-кB
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